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Bioinformatics Advance Access originally published online on December 10, 2004
Bioinformatics 2005 21(8):1737-1738; doi:10.1093/bioinformatics/bti209
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© The Author 2004. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

In silico fine-mapping: narrowing disease-associated loci by intergenomics

Pablo Serrano-Fernández 1,*, Saleh M. Ibrahim 1, Dirk Koczan 1, Uwe K. Zettl 2 and Steffen Möller 1

1Institute of Immunology, University of Rostock Schillingallee 70, D-18057 Rostock, Germany
2Institute of Neurology, University of Rostock Schillingallee 70, D-18057 Rostock, Germany

*To whom correspondence should be addressed.

Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was created to identify intergenomic consensuses to fine map QTLs and SLs in silico and select particularly promising candidate genes for such traits. Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits.

Availability: http://qtl.pzr.uni-rostock.de/qtlmix.php

Contact: serrano{at}pzr.uni-rostock.de


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