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Bioinformatics Advance Access originally published online on January 12, 2005
Bioinformatics 2005 21(9):2095-2096; doi:10.1093/bioinformatics/bti252
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

GOAnno: GO annotation based on multiple alignment

F. Chalmel 1,*, A. Lardenois 1, J.D. Thompson 1, J. Muller 1, J.-A. Sahel 2, T. Léveillard 2 and O. Poch 1

1Laboratoire de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP BP 163, 67404 Illkirch cedex, France
2Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, Inserm U592, Université Pierre et Marie Curie 75571 Paris, France

*To whom correspondence should be addressed.

Summary: GOAnno is a web tool that automatically annotates proteins according to the Gene Ontology (GO) using evolutionary information available in hierarchized multiple alignments. GO terms present in the aligned functional subfamily can be cross-validated and propagated to obtain highly reliable predicted GO annotation based on the GOAnno algorithm.

Availability: The web tool and a reduced version for local installation are freely available at http://igbmc.u-strasbg.fr/GOAnno/GOAnno.html

Contact: chalmel{at}igbmc.u-strasbg.fr

Supplementary information: The website supplies a detailed explanation and illustration of the algorithm at http://igbmc.u-strasbg.fr/GOAnno/GOAnnoHelp.html


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