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Bioinformatics Advance Access originally published online on January 28, 2005
Bioinformatics 2005 21(9):2130-2132; doi:10.1093/bioinformatics/bti293
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

TreeScan: a bioinformatic application to search for genotype/phenotype associations using haplotype trees

David Posada 1,*, Taylor J. Maxwell 2 and Alan R. Templeton 2

1Variagenics, Inc. 60 Hampshire Street, Cambridge, MA 02139, USA
2Department of Biology, Washington University St Louis, MO 63130–4899, USA

*To whom correspondence should be addressed at Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Campus Universitario, Universidad de Vigo, Vigo 36310, Spain.

Summary: We present the software implementation of the tree scanning method to detect associations between genetic haplotypes and quantitative traits, utilizing the evolutionary history of the haplotypes, in samples of unrelated individuals.

Availability: The program is available free of charge, under the GNU General Public License. A package including C source code, a Makefile, and Windows (DOS) and Macintosh binaries, can be downloaded from http://darwin.uvigo.es

Contact: dposada{at}uvigo.es


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