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Bioinformatics Advance Access originally published online on January 18, 2005
Bioinformatics 2005 21(9):2140-2141; doi:10.1093/bioinformatics/bti269
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology

Pedro A. Reche 1,2,*, Hong Zhang 1, John-Paul Glutting 1 and Ellis L. Reinherz 1,2

1Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute 77 Avenue Louis Pasteur, Boston, MA 02115, USA
2Department of Medicine, Harvard Medical School 77 Avenue Louis Pasteur, Boston, MA 02115, USA

*To whom correspondence should be addressed.

Summary: EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EPIMHC database is accessible through a web server that has been designed to facilitate research in computational vaccinology. Importantly, peptides resulting from a query can be selected to derive specific motif-matrices. Subsequently, these motif-matrices can be used in combination with a dynamic algorithm for predicting MHC-binding peptides from user-provided protein queries.

Availability: The EPIMHC database server is hosted by the Dana-Farber Cancer Institute at the site http://immunax.dfci.harvard.edu/bioinformatics/epimhc/

Contact: reche{at}research.dfci.harvard.edu


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