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Bioinformatics 2005 21(Suppl 2):ii137-ii143; doi:10.1093/bioinformatics/bti1123
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oxfordjournals.org

Fusing microarray experiments with multivariate regression

Walter R. Gilks 1,*, Brian D. M. Tom 1 and Alvis Brazma 2

1MRC Biostatistics Unit Robinson Way, Cambridge, CB2 2SR, UK
2EMBL-EBI, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UK

*To whom correspondence should be addressed.

Motivation: It is widely acknowledged that microarray data are subject to high noise levels and results are often platform dependent. Therefore, microarray experiments should be replicated several times and in several laboratories before the results can be relied upon. To make the best use of such extensive datasets, methods for microarray data fusion are required. Ideally, the fused data should distil important aspects of the data while suppressing unwanted sources of variation and be amenable to further informal and formal methods of analysis. Also, the variability in the quality of experimentation should be taken into account.

Results: We present such an approach to data fusion, based on multivariate regression. We apply our methodology to data from a previous study on cell-cycle control in Schizosaccharomyces pombe.

Availability: The algorithm implemented in R is freely available from the authors on request.

Contact: wally.gilks{at}mrc-bsu.cam.ac.uk


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