Bioinformatics Advance Access originally published online on March 1, 2006
Bioinformatics 2006 22(10):1166-1171; doi:10.1093/bioinformatics/btl073
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Family specific rates of protein evolution
Hannes Luz * and
Martin Vingron
Max Planck Institute for Molecular Genetics Ihnestrasse 73, 14195 Berlin, Germany
*To whom correspondence should be addressed.
Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins.
Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.
Contact: luz{at}molgen.mpg.de
Supplementary information: http://speeds.molgen.mpg.de
Received on November 30, 2005; revised on January 26, 2006; accepted on February 23, 2006
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