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Bioinformatics Advance Access originally published online on May 26, 2006
Bioinformatics 2006 22(15):1919-1920; doi:10.1093/bioinformatics/btl269
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

ACE-it: a tool for genome-wide integration of gene dosage and RNA expression data

Wessel N. van Wieringen 1, Jeroen A. M. Belien 2, Sjoerd J. Vosse 1, Eskeatnaf M. Achame 2 and Bauke Ylstra 2,*

1 Department of Mathematics, Vrije Universiteit De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands
2 Department of Pathology, VU Medical Center PO Box 7057, 1007 MB, Amsterdam, The Netherlands

*To whom correspondence should be addressed.

Summary: We describe a tool, called ACE-it (Array CGH Expression integration tool). ACE-it links the chromosomal position of the gene dosage measured by array CGH to the genes measured by the expression array. ACE-it uses this link to statistically test whether gene dosage affects RNA expression.

Availability: ACE-it is freely available at http://ibivu.cs.vu.nl/programs/acewww/

Contact: b.ylstra{at}vumc.nl

Supplementary Information: Programs, the manual and supplementary information are available on the website.

Received on February 21, 2006; revised on April 24, 2006; accepted on May 19, 2006

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W. N. Van Wieringen, M. A. Van De Wiel, and B. Ylstra
Weighted clustering of called array CGH data
Biostat., July 1, 2008; 9(3): 484 - 500.
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