Bioinformatics Advance Access originally published online on May 23, 2006
Bioinformatics 2006 22(15):1928-1929; doi:10.1093/bioinformatics/btl268
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© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
SNPStats: a web tool for the analysis of association studies
1 Catalan Institute of Oncology, IDIBELL, Epidemiology and Cancer Registry L'Hospitalet, Barcelona, Spain
2 Autonomous University of Barcelona, Laboratory of Biostatistics and Epidemiology Bellaterra, Barcelona, Spain
*To whom correspondence should be addressed.
Summary: A web-based application has been designed from a genetic epidemiology point of view to analyze association studies. Main capabilities include descriptive analysis, test for Hardy–Weinberg equilibrium and linkage disequilibrium. Analysis of association is based on linear or logistic regression according to the response variable (quantitative or binary disease status, respectively). Analysis of single SNPs: multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive), and analysis of interactions (gene–gene or gene–environment). Analysis of multiple SNPs: haplotype frequency estimation, analysis of association of haplotypes with the response, including analysis of interactions.
Availability: http://bioinfo.iconcologia.net/SNPstats. Source code for local installation is available under GNU license.
Contact: v.moreno{at}iconcologia.net
Supplementary Information: Figures with a sample run are available on Bioinformatics online. A detailed online tutorial is available within the application.
Received on March 6, 2006; revised on May 16, 2006; accepted on May 18, 2006
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