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Bioinformatics Advance Access originally published online on June 20, 2006
Bioinformatics 2006 22(16):2053-2054; doi:10.1093/bioinformatics/btl331
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

HCNet: a database of heart and calcium functional network

Seong-Eui Hong 1,{dagger}, Seong-Hwan Rho 1,{dagger}, Young Il Yeom 2 and Do Han Kim 1,*

1 Department of Life Science, Gwangju Institute of Science and Technology 1 Oryong-dong, Buk-gu, Gwangju 500-712, Korea
2 Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology Deajeon, Korea

*To whom correspondence should be addressed.


  Abstract

Summary: The Heart and Calcium functional Network (HCNet) database is a collection of functional gene modules calculated from the microarray data compendium available from the GEO database. It is a specialized database designed to assist experimentalists for cardiac calcium signaling research by providing the pre-calculated gene clusters and their potential correlation network in heart.

In the current release of HCNet, 57 functional modules from 786 target genes obtained by a bi-clustering analysis of 381 microarray datasets are available. Detailed information of the clusters such as expression profiles, network diagrams is provided in two categories, heart-specific genes and heart-specific genes along with calcium toolkit genes. Overrepresented gene ontological categories and transcription factors in each cluster are also provided to infer the biological implications of the detected functional modules.

Availability: HCNet is available at http://sbrg2.gist.ac.kr/hcnet

Contact: dhkim{at}gist.ac.kr

{dagger}The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.

Associate Editor: Golan Yona

Received on April 12, 2006; revised on June 7, 2006; accepted on June 9, 2006

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