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The-more-the-better and the-less-the-better
The Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute of Medical Research, North Shore LIJ Health System Manhasset, NY 11030, USA
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To many biologists, geneticists and bioinformaticians, the excitement of genomics comes from systematic analyses of large amounts of information, such as complete end-to-end DNA sequences, densely packed genetic markers on chromosomes, and sometimes, comprehensive population genetics history in places like Iceland and Finland where extensive genealogical data are available. Also, realizing the importance of sample sizes in mapping susceptibility genes in complex and common diseases, various national and international consortiums were established, and meta analyses were frequently in use on pooled data. Almost everybody agrees that ‘the more (information), the better’.
There are two senses in the word ‘more’ used here. One concerns the search space, and another concerns the sample size. It is easy to understand why one would like to see