APDB: a web server to evaluate the accuracy of sequence alignments using structural information
1 CNRS UPR2589, Institute for Structural Biology and Microbiology (IBSM), Parc Scientifique de Luminy 163 Avenue de Luminy, FR-13288, Marseille cedex 09, France
2 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin Ireland
3 Institut Suisse de Recherche et d'Experimentation sur le Cancer, Ch. des Boveresses 155 CH-1066 Epalinges Switzerland
*To whom correspondence should be addressed.
Summary: The APDB webserver uses structural information to evaluate the alignment of sequences with known structures. It returns a score correlated to the overall alignment accuracy as well as a local evaluation. Any sequence alignment can be analyzed with APDB provided it includes at least two proteins with known structures. Sequences without a known structure are simply ignored and do not contribute to the scoring procedure.
Availability: APDB is part of the T-Coffee suite of tools for alignment analysis, it is available on www.tcoffee.org. A standalone version of the package is also available as a freeware open source from the same address.
Contact: cedric.notredame{at}europe.com
Received on March 31, 2006; revised on June 17, 2006; accepted on July 21, 2006