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Bioinformatics 2006 22(19):2439-2440; doi:10.1093/bioinformatics/btl404
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

APDB: a web server to evaluate the accuracy of sequence alignments using structural information

Fabrice Armougom 1, Olivier Poirot 1, Sébastien Moretti 1, Desmond G. Higgins 2, Phillip Bucher 3, Vladimir Keduas 1 and Cedric Notredame 1,*

1 CNRS UPR2589, Institute for Structural Biology and Microbiology (IBSM), Parc Scientifique de Luminy 163 Avenue de Luminy, FR-13288, Marseille cedex 09, France
2 The Conway Institute of Biomolecular and Biomedical Research, University College Dublin Ireland
3 Institut Suisse de Recherche et d'Experimentation sur le Cancer, Ch. des Boveresses 155 CH-1066 Epalinges Switzerland

*To whom correspondence should be addressed.

Summary: The APDB webserver uses structural information to evaluate the alignment of sequences with known structures. It returns a score correlated to the overall alignment accuracy as well as a local evaluation. Any sequence alignment can be analyzed with APDB provided it includes at least two proteins with known structures. Sequences without a known structure are simply ignored and do not contribute to the scoring procedure.

Availability: APDB is part of the T-Coffee suite of tools for alignment analysis, it is available on www.tcoffee.org. A standalone version of the package is also available as a freeware open source from the same address.

Contact: cedric.notredame{at}europe.com


Received on March 31, 2006; revised on June 17, 2006; accepted on July 21, 2006

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