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Bioinformatics Advance Access originally published online on January 12, 2006
Bioinformatics 2006 22(6):771-772; doi:10.1093/bioinformatics/btk049
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Maximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting

Alun Thomas * and Nicola J. Camp

Department of Medical Informatics, University of Utah 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA

*To whom correspondence should be addressed.

Summary: Graphical modeling is used to extend the gene counting method to compute maximum likelihood estimates of allele frequencies for samples of individuals related in extended pedigrees. Genotypes may be missing or partially observed, and error rates can be simultaneously estimated.

Availability: The Java classes and Javadocs pages for Formulacan be obtained from bioinformatics.med.utah.edu/~alun, which also has more information on its use and file formats.

Contact: alun{at}genepi.med.utah.edu

Received on November 7, 2005; revised on January 6, 2006; accepted on January 9, 2006

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