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Bioinformatics Advance Access originally published online on January 19, 2006
Bioinformatics 2006 22(6):773-774; doi:10.1093/bioinformatics/btk031
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

SUSPECTS: enabling fast and effective prioritization of positional candidates

E. A. Adie *, R. R. Adams , K. L. Evans , D. J. Porteous and B. S. Pickard

Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK

*To whom correspondence should be addressed at MMC, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK

Summary: SUSPECTS is a web-based server which combines annotation and sequence-based approaches to prioritize disease candidate genes in large regions of interest. It uses multiple lines of evidence to rank genes quickly and effectively while limiting the effect of annotation bias to significantly improve performance.

Availability: SUSPECTS is freely available at http://www.genetics.med.ed.ac.uk/suspects/

Contact: euan.adie{at}ed.ac.uk

Supplementary information: A quick-start guide in Macromedia Flash format is available at http://www.genetics.med.ed.ac.uk/suspects/help.shtml and Excel spreadsheets detailing the comparative performance of the software are included as Supplementary material.

Received on October 26, 2005; revised on December 12, 2005; accepted on December 28, 2005

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