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Bioinformatics Advance Access originally published online on March 1, 2006
Bioinformatics 2006 22(8):1015-1017; doi:10.1093/bioinformatics/btl072
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© The Author 2006. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

PIANA: protein interactions and network analysis

Ramon Aragues , Daniel Jaeggi and Baldo Oliva *

Structural Bioinformatics Group (GRIB–IMIM). Departament de Ciències Experimentals i de la Salut. Universitat Pompeu Fabra C/Doctor Aiguader, 83, Barcelona 08003, Catalonia, Spain

*To whom correspondence should be addressed.

Summary: We present a software framework and tool called Protein Interactions And Network Analysis (PIANA) that facilitates working with protein interaction networks by (1) integrating data from multiple sources, (2) providing a library that handles graph-related tasks and (3) automating the analysis of protein–protein interaction networks. PIANA can also be used as a stand-alone application to create protein interaction networks and perform tasks such as predicting protein interactions and helping to identify spots in a 2D electrophoresis gel.

Availability: PIANA is under the GNU GPL. Source code, database and detailed documentation may be freely downloaded from http://sbi.imim.es/piana.

Contact: ramon.aragues{at}upf.edu; boliva{at}imim.es

Received on December 16, 2005; revised on February 8, 2006; accepted on February 23, 2006

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