Skip Navigation


Bioinformatics Advance Access originally published online on March 7, 2007
Bioinformatics 2007 23(14):1815-1823; doi:10.1093/bioinformatics/btm084
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (Print PDF) Freely available
Right arrow Supplementary Data
Right arrow All Versions of this Article:
23/14/1815    most recent
btm084v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bhasi, A.
Right arrow Articles by Senapathy, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bhasi, A.
Right arrow Articles by Senapathy, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EuSplice: a unified resource for the analysis of splice signals and alternative splicing in eukaryotic genes

Ashwini Bhasi 1, Ram Vinay Pandey 2, Suriya Prabha Utharasamy 2 and Periannan Senapathy 1,*

1Department of Human Genetics, Genome Technologies, Inc., 8000 Excelsior Drive, Madison, WI 53717, USA and 2Department of Bioinformatics, International Center for Advanced Genomics and Proteomics, 383 1st Cross Street, Nehru Nagar, Chennai 600096, India

*To whom correspondence should be addressed.


  Abstract

Motivation: Despite increased availability of genome annotation data, a comprehensive resource for in-depth analysis of splice signal distributions and alternative splicing (AS) patterns in eukaryote genomes is still lacking. To meet this need, we have developed EuSplice—a unique splice-centric database which provides reliable splice signal and AS information for 23 eukaryotes.

Results: The EuSplice database contains 95 822 AS events and 2.1 million splice signals associated with over 270 000 protein-coding genes. The intuitive, user-friendly EuSplice web interface has powerful data mining and graphics capabilities for inter-genomic comparative analysis of splice signals, putative cryptic splice sites and AS events. Moreover, the seamless integration of splicing data to extensive gene-specific annotations, such as homolog annotations, functional information, mutations and sequence details makes EuSplice a powerful one-stop information resource for investigating the molecular mechanisms of complex splicing events, disease associations and the evolution of splicing in eukaryotes.

Availability: http://66.170.16.154/EuSplice

Contact: ps{at}genome.com

Supplementary information: Supplementary tables and figures at Bioinfo online.

Associate Editor: Alex Bateman

Received on November 17, 2006; revised on January 20, 2007; accepted on March 1, 2007

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.