Skip Navigation


Bioinformatics Advance Access originally published online on June 22, 2007
Bioinformatics 2007 23(16):2190-2192; doi:10.1093/bioinformatics/btm316
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (Print PDF) Freely available
Right arrowOA All Versions of this Article:
23/16/2190    most recent
btm316v1
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Laramie, J. M.
Right arrow Articles by Myers, R. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laramie, J. M.
Right arrow Articles by Myers, R. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies

Jason M. Laramie 1,2,*, Jemma B. Wilk 1,3, Anita L. DeStefano 1,4 and Richard H. Myers 1,2,3

1Department of Neurology, Boston University School of Medicine, Boston, MA, 2Program in Bioinformatics, Boston University, Boston, MA, 3Department of Medicine, Boston University School of Medicine, Boston, MA and 4Department of Biostatistics, Boston University School Of Public Health, Boston, MA, USA

*To whom correspondence should be addressed.


  Abstract

Summary: We have created a program that searches densely genotyped regions for associated non-contiguous haplotypes using a standard family based haplotype association test. This program was designed to expand upon the ‘sliding window’ methodologies commonly used for haplotype construction by allowing the association of subsets of single nucleotide polymorphisms (SNPs) to drive the construction of the haplotype. This strategy permits HaploBuild to construct more biologically relevant haplotypes that are not constrained by arbitrary length and contiguous orientation.

Availability: http://snp.bumc.bu.edu

Contact: laramiej{at}bu.edu

Associate Editor: Keith Crandall

Received on March 20, 2007; revised on May 9, 2007; accepted on June 6, 2007

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
E. E. Kenny, A. Gusev, K. Riegel, D. Lutjohann, J. K. Lowe, J. Salit, J. B. Maller, M. Stoffel, M. J. Daly, D. M. Altshuler, et al.
Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae
PNAS, August 18, 2009; 106(33): 13886 - 13891.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
R. Abo, S. Knight, J. Wong, A. Cox, and N. J. Camp
hapConstructor: automatic construction and testing of haplotypes in a Monte Carlo framework
Bioinformatics, September 15, 2008; 24(18): 2105 - 2107.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.