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Bioinformatics Advance Access originally published online on July 27, 2007
Bioinformatics 2007 23(19):2643-2644; doi:10.1093/bioinformatics/btm376
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

AssociationDB: web-based exploration of genomic association

Dominik Seelow 1,*, Katrin Hoffmann 1,2 and Tom H. Lindner 3

1Institute for Medical Genetics, Charité – Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, 2Max Planck Institute for Molecular Genetics, Ihnestrasse. 73, D-14195 Berlin and 3Department of Nephrology and Hypertension, Medical Clinic 4, University of Erlangen-Nuremberg, Breslauer Strasse, 201, D-90471 Nürnberg, Germany

*To whom correspondence should be addressed.


  Abstract

Summary: Genome-wide association studies use hundreds of thousands of markers making it challenging to present and finally interpret the results. We developed a graphical, web-based solution for an interactive exploration of the results of case-control studies, with a tight integration of related gene information and tissue-specific expression data. Association results are presented as physical position-based vertical bars with known genes included as horizontal bars at their respective physical positions. The interface allows the specification of filtering criteria for the association data and highlights potentially interesting genes with user-specified terms occurring in their reports or with relevant expression patterns. Pop-up windows and hyperlinks provide drill-down capabilities and quick access to relevant data AssociationDB can either be used as a stand-alone solution or as a front-end joining association results obtained by other software with genomic information.

Availability: http://genetik.charite.de/AssociationDB

Contact: dominik.seelow{at}charite.de

Supplementary information: The source code, a web-based demo, a step-by-step manual, and an installation guide are available at http://genetik.charite.de/AssociationDB.

Associate Editor: Alex Bateman

Received on December 11, 2006; revised on May 31, 2007; accepted on July 14, 2007

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