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Bioinformatics Advance Access originally published online on July 28, 2007
Bioinformatics 2007 23(19):2645-2647; doi:10.1093/bioinformatics/btm383
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© The Author 2007. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Flavitrack: an annotated database of flavivirus sequences

Milind Misra 1,{dagger} and Catherine H. Schein 1,2,3,*

1Department of Biochemistry and Molecular Biology and 2Department of Microbiology and Immunology, Sealy Center for Structural Biology and Molecular Biophysics and 3Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 77555-0857, USA

*To whom correspondence should be addressed.


  Abstract

Motivation: Properly annotated sequence data for flaviviruses, which cause diseases, such as tick-borne encephalitis (TBE), dengue fever (DF), West Nile (WN) and yellow fever (YF), can aid in the design of antiviral drugs and vaccines to prevent their spread. Flavitrack was designed to help identify conserved sequence motifs, interpret mutational and structural data and track evolution of phenotypic properties.

Summary: Flavitrack contains over 590 complete flavivirus genome/protein sequences and information on known mutations and literature references. Each sequence has been manually annotated according to its date and place of isolation, phenotype and lethality. Internal tools are provided to rapidly determine relationships between viruses in Flavitrack and sequences provided by the user.

Availability: http://carnot.utmb.edu/flavitrack

Contact: chschein{at}utmb.edu

Supplementary information: http://carnot.utmb.edu/flavitrack/B1S1.html

{dagger}Present address: Computational Biosciences Department, Sandia National Laboratories, PO Box 5800 MS-1413, Albuquerque, NM 87185-1413, USA.

Associate Editor: Jonathan Wren

Received on April 4, 2007; revised on June 22, 2007; accepted on July 10, 2007

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