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Bioinformatics Advance Access originally published online on October 31, 2007
Bioinformatics 2007 23(22):3088-3090; doi:10.1093/bioinformatics/btm512
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

CONSORF: a consensus prediction system for prokaryotic coding sequences

Sungsoo Kang 1, Sung-Jin Yang 1, Sangsoo Kim 2,* and Jong Bhak 1,*

1KOBIC (Korean BioInformation Center), KRIBB, Daejeon 305-806 and 2Soongsil University, 1-1 Sangdo-dong, Dongjak-gu, Seoul 156-743, Korea

*To whom correspondence should be addressed.


   Abstract

Summary: CONSORF is a fully automatic high-accuracy identification system that provides consensus prokaryotic CDS information. It first predicts the CDSs supported by consensus alignments. The alignments are derived from multiple genome-to-proteome comparisons with other prokaryotes using the FASTX program. Then, it fills the empty genomic regions with the CDSs supported by consensus ab initio predictions. From those consensus results, CONSORF provides prediction reliability scores, predicted frame-shifts, alternative start sites and best pair-wise match information against other prokaryotes. These results are easily accessed from a website.

Availability: The regularly updated CDS predictions of prokaryotic genomes as well as the source code are freely accessible through http://consorf.kobic.re.kr and http://orfome.org.

Contact: j{at}bio.cc, jong{at}kribb.re.kr or sskimb{at}ssu.ac.kr

Supplementary information: The detailed methods and evaluation results can be found at http://consorf.kobic.re.kr/supplementary/.

Associate Editor: Alfonso Valencia


Received on May 18, 2007; revised on September 20, 2007; accepted on October 8, 2007

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