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Bioinformatics Advance Access originally published online on April 15, 2008
Bioinformatics 2008 24(11):1408-1409; doi:10.1093/bioinformatics/btn179
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Forward-time simulations of non-random mating populations using simuPOP

Bo Peng * and Christopher I. Amos

Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX, 77030, USA

*To whom correspondence should be addressed.


   Abstract

Summary: Computer simulations play an important role in studies of non-random mating populations. Because of implementation difficulties, only very limited types of non-random mating schemes are provided in the currently available simulation programs. Starting with version 0.8.5, simuPOP provides a few mating schemes that can be used to simulate arbitrary non-random mating models. This article describes the concepts and methods behind these mating schemes and demonstrates their uses in a few examples, including partial self-mating, positive assortative mating, non-random outbreeding, and simulation of overlapping generations in age-structured populations.

Availability: simuPOP is freely available at http://simupop.sourceforge.net, distributed under a GPL license. Cited examples are in the doc/cookbook directory of a simuPOP distribution.

Contact: bpeng{at}mdanderson.org

Associate Editor: Martin Bishop


Received on March 7, 2008; revised on April 4, 2008; accepted on April 14, 2008

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