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Bioinformatics Advance Access originally published online on May 22, 2008
Bioinformatics 2008 24(13):1554-1555; doi:10.1093/bioinformatics/btn238
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A Bayesian estimator of protein–protein association probabilities

Jason M. Gilmore 1, Deanna L. Auberry 1, Julia L. Sharp 2, Amanda M. White 1, Kevin K. Anderson 1 and Don S. Daly 1,*

1Pacific Northwest National Laboratory, Battelle Boulevard, Richland, WA 99352 and 2Department of Applied Economics and Statistics, Clemson University, Clemson, SC 29634, USA

*To whom correspondence should be addressed.


  Abstract

Summary: The Bayesian Estimator of Protein–Protein Association Probabilities (BEPro aff3) is a software tool for estimating probabilities of protein–protein association between bait and prey protein pairs using data from multiple-bait, multiple-replicate, protein liquid chromatography tandem mass spectrometry LC–MS/MS affinity isolation experiments.

Availability: BEPro 3 is public domain software, has been tested on WIndows XP, Linux and Mac OS, and is freely available from http://www.pnl.gov/statistics/BEPro3.

Contact: ds.daly{at}pnl.gov

Supplementary Information: A user guide, example dataset with analysis and additional documentation are included with the BEPro 3 download.

Associate Editor: Burkhard Rost

Received on October 8, 2008; revised on May 15, 2008; accepted on May 15, 2008

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