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Bioinformatics Advance Access originally published online on July 19, 2008
Bioinformatics 2008 24(17):1953-1954; doi:10.1093/bioinformatics/btn341
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

PIGS: automatic prediction of antibody structures

Paolo Marcatili 1, Alessandra Rosi 1 and Anna Tramontano 1,2,*

1Department of Biochemical Sciences and 2Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University, P.le A. Moro 5, 00185 Rome, Italy

*To whom correspondence should be addressed.


  Abstract

Summary: We describe a web server for the automatic prediction of immunoglobulin variable domains based on the canonical structure model. The server is user-friendly and flexible. It allows the user to select the templates for the frameworks and the loops using different strategies. The final output is a full-fledged 3D model of the variable domains of the target immunoglobulin.

Availability: The server is openly accessible to academic users at the address: http://arianna.bio.uniroma1.it/pigs. It does not require registration and there is no limit to the number of sequences that can be submitted.

Contact: anna.tramontano{at}uniroma1.it

Associate Editor: Alfonso Valencia

Received on April 19, 2008; revised on June 17, 2008; accepted on July 2, 2008

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This article has been cited by other articles:


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A. Sircar, E. T. Kim, and J. J. Gray
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[Abstract] [Full Text] [PDF]


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