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Bioinformatics Advance Access originally published online on July 25, 2008
Bioinformatics 2008 24(20):2409-2411; doi:10.1093/bioinformatics/btn388
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© The Author 2008. Published by Oxford University Press. All rights reserved. For Permissions, pleaseemail: journals. permissions@oxfordjournals.org

dbNEI2.0: building multilayer network for drug–NEI–disease

Jing Zhang , Tao Ma , Yanda Li and Shao Li *

MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China

*To whom correspondence should be addressed.


  Abstract

Summary: The neuro-endocrine-immune (NEI) system plays a critical regulatory role in modulating host homeostasis and optimizing health. We created the dbNEI 2 years ago to collect NEI molecules and interactions. For transferring the conceptual NEI to the systematic NEI network and uncovering the NEI's medical function, we updated the dbNEI 2.0 in three ways: (i) extended NEI molecules to 2242 genes and 7657 chemical compounds by using gene ontology-based (GO-based) data mining strategy, (ii) added multilayer interactions of NEI molecules including KEGG signal transduction and metabolic pathways, HPRD protein–protein interactions (PPI), transcription factor and microRNA regulations and (iii) connected 611 drugs and 823 diseases through multilayer NEI interactions. The reconstructed drug–NEI–disease network will facilitate the systematic study of NEI system.

Availability: http://bioinfo.au.tsinghua.edu.cn/dbNEIweb/

Contact: shaoli{at}mail.tsinghua.edu.cn

Associate Editor: Dmitrij Frishman

Received on April 9, 2008; revised on July 14, 2008; accepted on July 24, 2008

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