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Bioinformatics Advance Access originally published online on November 13, 2008
Bioinformatics 2009 25(1):141-143; doi:10.1093/bioinformatics/btn590
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© The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

CRONOS: the cross-reference navigation server

Brigitte Waegele 1,*, Irmtraud Dunger-Kaltenbach 1, Gisela Fobo 1, Corinna Montrone 1, H.-Werner Mewes 1,2 and Andreas Ruepp 1

1Institute for Bioinformatics and Systems Biology (MIPS), Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, D-85764 Neuherberg and 2Chair of Genome-oriented Bioinformatics, Life and Food Science Center Weihenstephan, Am Forum 1, Technische Universität München, Life and Food Science Center Weihenstephan, Am Forum 1, D-85354 Freising-Weihenstephan, Germany

*To whom correspondence should be addressed.


  Abstract

Summary: Cross-mapping of gene and protein identifiers between different databases is a tedious and time-consuming task. To overcome this, we developed CRONOS, a cross-reference server that contains entries from five mammalian organisms presented by major gene and protein information resources. Sequence similarity analysis of the mapped entries shows that the cross-references are highly accurate. In total, up to 18 different identifier types can be used for identification of cross-references. The quality of the mapping could be improved substantially by exclusion of ambiguous gene and protein names which were manually validated. Organism-specific lists of ambiguous terms, which are valuable for a variety of bioinformatics applications like text mining are available for download.

Availability: CRONOS is freely available to non-commercial users at http://mips.gsf.de/genre/proj/cronos/index.html, web services are available at http://mips.gsf.de/CronosWSService/CronosWS?wsdl.

Contact: brigitte.waegele{at}helmholtz-muenchen.de

Supplementary information: Supplementary data are available at Bioinformatics online. The online Supplementary Material contains all figures and tables referenced by this article.

Associate Editor: Martin Bishop

Received on August 13, 2008; revised on November 11, 2008; accepted on November 11, 2008

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This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
A. Ruepp, B. Waegele, M. Lechner, B. Brauner, I. Dunger-Kaltenbach, G. Fobo, G. Frishman, C. Montrone, and H.-W. Mewes
CORUM: the comprehensive resource of mammalian protein complexes--2009
Nucleic Acids Res., November 1, 2009; (2009) gkp914v1.
[Abstract] [Full Text] [PDF]


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