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Bioinformatics Advance Access originally published online on March 31, 2009
Bioinformatics 2009 25(11):1428-1430; doi:10.1093/bioinformatics/btp180
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Hooke: an open software platform for force spectroscopy

Massimo Sandal 1,*, Fabrizio Benedetti 1, Marco Brucale 1, Alberto Gomez-Casado 2 and Bruno Samorì 1

1Department of Biochemistry ‘G.Moruzzi’, Via Irnerio 48, 40126 Bologna, Italy and 2MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands

*To whom correspondence should be addressed.


  Abstract

Summary: Hooke is an open source, extensible software intended for analysis of atomic force microscope (AFM)-based single molecule force spectroscopy (SMFS) data. We propose it as a platform on which published and new algorithms for SMFS analysis can be integrated in a standard, open fashion, as a general solution to the current lack of a standard software for SMFS data analysis. Specific features and support for file formats are coded as independent plugins. Any user can code new plugins, extending the software capabilities. Basic automated dataset filtering and semi-automatic analysis facilities are included.

Availability: Software and documentation are available at http://code.google.com/p/hooke. Hooke is a free software under the GNU Lesser General Public License.

Contact: massimo.sandal{at}unibo.it

Associate Editor: Alfonso Valencia

Received on January 22, 2009; revised on March 10, 2009; accepted on March 25, 2009

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