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Bioinformatics Advance Access originally published online on April 15, 2009
Bioinformatics 2009 25(12):1564-1565; doi:10.1093/bioinformatics/btp253
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria–Delbrück fluctuation analysis

Brandon M. Hall 1,*, Chang-Xing Ma 2, Ping Liang 3 and Keshav K. Singh 1

1Department of Cancer Genetics, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, 2Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA and 3Department of Biological Sciences, Brock University, St. Catharines, Ontario L2S 3A1, Canada

*To whom correspondence should be addressed.


  Abstract

Summary:The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria–Delbrück fluctuation analysis to calculate the frequency and rate from various mutation assays in bacteria and yeast. Three calculation methods are available through this program: (i) Ma-Sandri-Sarkar Maximum Likelihood Estimator (MSS-MLE) method, (ii) Lea-Coulson method of the median (LC) and (iii) frequency.

Availability: The FALCOR rate calculator is currently accessible at http://www.mitochondria.org/protocols/FALCOR.html. This program is written as a JavaTM Applet, requiring a web browser enabled with Sun MicroSystems' Java Virtual Machine.

Contact: brandon.hall@roswellpark.org

Associate Editor: Martin Bishop

Received on December 31, 2008; revised on April 7, 2009; accepted on April 8, 2009

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