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Bioinformatics Advance Access originally published online on May 12, 2009
Bioinformatics 2009 25(15):1991-1993; doi:10.1093/bioinformatics/btp299
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

DIANA-mirPath: Integrating human and mouse microRNAs in pathways

G. L. Papadopoulos 1,*, P. Alexiou 1, M. Maragkakis 1, M. Reczko 1,3 and A. G. Hatzigeorgiou 1,2,*

1 Institute of Molecular Oncology, Biomedical Sciences Research Center "Alexander Fleming", 16602 Varkiza, Greece, 2 Computer and Information Sciences, University of Pennsylvania, Philadelphia, PA, USA and 3 Synaptic Ltd., Heraklion, Greece

* To whom correspondence should be addressed.


  Abstract

Summary: DIANA-mirPath is a web-based computational tool developed to identify molecular pathways potentially altered by the expression of single or multiple microRNAs. The software performs an enrichment analysis of multiple microRNA target genes comparing each set of microRNA targets to all known KEGG pathways. The combinatorial effect of co-expressed microRNAs in the modulation of a given pathway is taken into account by the simultaneous analysis of multiple microRNAs. The graphical output of the program provides an overview of the parts of the pathway modulated by microRNAs, facilitating the interpretation and presentation of the analysis results.

Availability: The software is available at http://microrna.gr/mirpath and is free for all users with no login or download requirement.

Contact: papadopoulos{at}fleming.gr or hatzigeorgiou{at}fleming.gr

Associate Editor: Ivo Hofacker

Received on March 9, 2009; revised on April 23, 2009; accepted on April 28, 2009

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