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Bioinformatics Advance Access published online on February 5, 2004
Bioinformatics, doi:10.1093/bioinformatics/btg481
Bioinformatics © Oxford University Press 2004; all rights reserved
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Revised August 21, 2003
Accepted October 14, 2003

Applications note

Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity

Jakob C. Mueller 1* Christophe Andreoli 1

1 Institute of Human Genetics, GSF, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

* To whom correspondence should be addressed. E-mail: jakob.mueller{at}gsf.de.


  Abstract

Association studies may request more details of a specific haplotype. Haplotype-specific decay of linkage disequilibrium is such a crucial and versatile characteristic. It may be used, for example, to search for signals of natural selection in a risk haplotype. Here, we present a web-based tool to explore the relationship between population frequency and extended linkage disequilibrium measured as haplotype homozygosity of observed haplotypes within a specified candidate region.

Availability: The web-tool is available at http://ihg.gsf.de/cgi-bin/mueller/webehh.pl.


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