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Bioinformatics Advance Access published online on March 25, 2004
Bioinformatics, doi:10.1093/bioinformatics/bth191
Bioinformatics © Oxford University Press 2004; all rights reserved
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Received September 17, 2003
Revised January 28, 2004
Accepted February 19, 2004

Applications note

UniProt Archive

Rasko Leinonen 1, Federico Garcia Diez 1, David Binns 1, Wolfgang Fleischmann 1, Rodrigo Lopez 1, Rolf Apweiler 1*

1 EMBL Outstation The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

* To whom correspondence should be addressed. E-mail: rolf.apweiler{at}ebi.ac.uk.


  Abstract

Summary: UniProt Archive (UniParc) is the most comprehensive, non-redundant protein sequence database available. Its protein sequences are retrieved from predominant publicly accessible resources. All new and updated protein sequences are collected and loaded daily into UniParc for full coverage. To avoid redundancy, each unique sequence is stored only once with a stable protein identifier, which can later be used in UniParc to identify the same protein in all source databases. When proteins are loaded into the database, database cross-references are created to link them to the origins of the sequences. As a result, performing a sequence search against UniParc is equivalent to performing the same search against all databases cross-referenced by UniParc. UniParc contains only protein sequences and database cross-references, all other information must be retrieved from the source databases.

Availability: http://www.ebi.ac.uk/uniparc/.


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