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Bioinformatics Advance Access published online on September 3, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti009
Bioinformatics © Oxford University Press 2004; all rights reserved
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Received July 14, 2004
Revised August 30, 2004
Accepted August 31, 2004

Applications note

easyLINKAGE: A PERL script for easy and automated two-/multi-point linkage analyses

T. H. Lindner 1* and K. Hoffmann 2

1 Division of Nephrology, Department of Medicine, Medical University Clinic at the University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany
2 Institute of Medical Genetics, Charité, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

* To whom correspondence should be addressed. E-mail: tom.lindner{at}mail.uni-wuerzburg.de.


  Abstract

Summary: We have generated the program easyLINKAGE that combines automated setup and performance of linkage analyses and simulation under an easy to handle graphical user interface for Microsoft Windows 2000/XP and standard UNIX systems. The program package supports two-point linkage analyses (FastLink v4.1, SPLink v1.09), multi-point linkage analyses (GENEHUNTER v2.1, GENEHUNTER-PLUS with the emendation by Kong and Cox v1.2 (allele sharing modelling)), and the simulation package SLINK v2.65, and provides genome-wide as well as chromosomal postscript plots of LOD scores, NPL scores, P values, and other parameters.

Availability: http://www.uni-wuerzburg.de/nephrologie/molecular_genetics/molecular_genetics.htm.

Supplementary information: Supplementary information is available on the website.


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