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Bioinformatics Advance Access published online on September 9, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti017
Bioinformatics © Oxford University Press 2004; all rights reserved
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Received June 29, 2004
Revised August 23, 2004
Accepted September 2, 2004

Article

Human-mouse gene searcher: a tool to assist discovery of malformation-associated genes by using phenotype databases

Ian Bradford 1*, Robin Winter** 1, Carl Evans 2, and Jonathan Bard 3

1 Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
2 School of Computing Science, Middlesex University, EH8 9XD, UK
3 Bioinformatics, Medical School, University of Edinburgh, EH8 9XD, UK

* To whom correspondence should be addressed. E-mail: i.bradford{at}ich.ucl.ac.uk.


  Abstract

An open-access World Wide Web application has been developed that enables the cross-linking of anatomical data on the phenotypic manifestations of human and mouse malformation syndromes to data on gene function and/or expression patterns in the mouse GXD database. Ultimately, the system has been designed to assist biologists in the process of discovering hitherto unidentified malformation genes. More specifically, it facilitates search from the phenotypic level. The application and further information is available at http://genetics.ich.ucl.ac.uk/linksearchtool.

** Deceased


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