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Bioinformatics Advance Access published online on September 16, 2004

Bioinformatics, doi:10.1093/bioinformatics/bti035
Bioinformatics © Oxford University Press 2004; all rights reserved
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Received July 14, 2004
Revised September 3, 2004
Accepted September 10, 2004

Applications note

TPatternHunter: Gapped, fast and sensitive translated homology search

Derek Kisman 1, Ming Li 2, Bin Ma 3*, and Li Wang 3

1 Bioinformatics Solutions Inc., 145 Columbia St. West, Waterloo, Ont. Canada, N2L 3L2
2 School of Computer Science, University of Waterloo, Ont. N2L 3G1, Canada
3 Department of Computer Science, University of Western Ontario, London, Ont. N6A 5B7

* To whom correspondence should be addressed. E-mail: bma{at}csd.uwo.ca.


   Abstract

Summary: New ideas, spaced seeds and gapped alignment before 6-frame translation, are implemented for translated homology search in tPatternHunter. The new software compares favorably over tBLASTx.

Availability: The software is free to the academics at http://www.bioinformaticssolutions.com/downloads/ph-academic/.


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