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Bioinformatics Advance Access published online on October 14, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti065
Bioinformatics © Oxford University Press 2004; all rights reserved
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Received September 6, 2004
Accepted October 8, 2004

Discovery note

OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats

Isabelle Callebaut 1* and Jean-Paul Mornon 1

1 Département de Biologie Structurale, LMCP, CNRS UMR7590, Universités Paris 6 & Paris 7, Case 115, 4 place Jussieu, 75252 Paris Cedex 05, France

* To whom correspondence should be addressed. E-mail: Isabelle.Callebaut{at}lmcp.jussieu.fr.


  Abstract

We describe here a novel domain, OCRE, which is shared by the recently identified angiogenic factor VG5Q and a specific family of RNA-binding motif proteins.

The OCRE domain is characterized by a five-fold, imperfectly repeated octameric sequence, which includes a triplet of often-conserved aromatic amino acids predicted to form a {beta}-strand and in which the slightly modified fifth repeat might act as a repeat terminator.

Although the function of this domain remains to be elucidated, the domain architecture of OCRE containing proteins and experimental data suggest a role in RNA metabolism and/or in signalling pathways activated by the tumor necrosis factor (TNF) superfamily of cytokines.


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