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Bioinformatics Advance Access published online on October 28, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti106
Bioinformatics © Oxford University Press 2004; all rights reserved
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Received April 11, 2004
Revised July 10, 2004
Accepted September 14, 2004

Applications note

GOChase: correcting errors from gene ontology-based annotations for gene products

Yu Rang Park 1, Chan Hee Park 1, and Ju Han Kim 2*

1 Seoul National University Biomedical Informatics (SNUBI), College of Medicine, Seoul 110-799, Korea
2 Seoul National University Biomedical Informatics (SNUBI), College of Medicine, Seoul 110-799, Korea; Human Genome Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea

* To whom correspondence should be addressed.
Ju Han Kim, E-mail: juhan{at}snu.ac.kr


  Abstract

Summary: The Gene Ontology (GO) is a controlled biological vocabulary that provides three structured networks of terms to describe biological processes, cellular components, and molecular functions. Many databases of gene products are annotated using the GO vocabularies. We found that some GO-updating operations are not easily traceable by the current biological databases and GO browsers. Consequently, numerous annotation errors arise and are propagated throughout biological databases and GO-based high-level analyses. GOChase is a set of web-based utilities to detect and correct the errors in GO-based annotations.

Availability: http://www.snubi.org/software/GOChase/.


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