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Bioinformatics Advance Access published online on December 17, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti188
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Received May 21, 2004
Accepted November 11, 2004

Article

Multidimensional support vector machines for visualization of gene expression data

D. Komura 1*, H. Nakamura 1, S. Tsutsumi 1, H. Aburatani 2, and S. Ihara 1

1 Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan
2 Genome Science Div., Center for Collaborative Research, The University of Tokyo, Tokyo 153-8904, Japan

* To whom correspondence should be addressed.
D. Komura, E-mail: komura{at}hal.rcast.u-tokyo.ac.jp


  Abstract

Motivation: Since DNA microarray experiments provide us with huge amount of gene expression data, they should be analyzed with statistical methods to extract the meanings of experimental results. Some dimensionality reduction methods such as Principal Component Analysis (PCA) are used to roughly visualize the distribution of high dimensional gene expression data. However, in the case of binary classification of gene expression data, PCA does not utilize class information when choosing axes. Thus clearly separable data in the original space may not be so in the reduced space used in PCA.

Results: For visualization and class prediction of gene expression data, we have developed a new SVM-based method called multidimensional SVMs, that generate multiple orthogonal axes. This method projects high dimensional data into lower dimensional space to exhibit properties of the data clearly and to visualize a distribution of the data roughly. Furthermore, the multiple axes can be used for class prediction. The basic properties of conventional SVMs are retained in our method: solutions of mathematical programming are sparse, and nonlinear classification is implemented implicitly through the use of kernel functions. The application of our method to the experimentally obtained gene expression datasets for patients' samples indicates that our algorithm is efficient and useful for visualization and class prediction.

Komura et al. (2004) Multidimensional Support Vector Machines for Visualization of Gene Expression Data. Symposium on Applied Computing, Proceedings of the 2004 ACM symposium on Applied computing, 175-179; http://doi.acm.org/10.1145/967900.967936

Copyright 2004 Association for Computing Machinery, Inc. Reprinted by permission. Direct permission requests to permissions@acm.org


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