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Bioinformatics Advance Access published online on December 10, 2004

Bioinformatics, doi:10.1093/bioinformatics/bti194
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Bioinformatics © Oxford University Press 2004; all rights reserved.
Received October 21, 2004
Revised November 11, 2004
Accepted November 26, 2004

Article

HESAS: HERVs expression and structure analysis system

Tae-Hyung Kim 1, Yeo-Jin Jeon 1, Woo-Yeon Kim 1, and Heui-Soo Kim 2*

1 PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University, Busan 609-735, Korea
2 PBBRC, Interdisciplinary Research Program of Bioinformatics, Pusan National University, Busan 609-735, Korea; Division of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Korea

* To whom correspondence should be addressed.
Heui-Soo Kim, E-mail: khs307{at}pusan.ac.kr


   Abstract

HESAS (HERVs Expression and Structure Analysis System) database was developed to understand the HERVs (Human Endogenous RetroViruses) that have an effect on the expression of human functional genes. The database products are generated by the exon-based EST clustering and reconstructing of partial HERV structures that result from various mutations during primate evolution. The expression types were classified according to the existence of splicing, transcriptional start, and polyadenylation signal sites. The database currently contains HERV information on 26981 human genes of exon-intron structure. The HERV elements were inserted into 17317 of these genes and linked to expression with 898 genes.

Availability: http://www.primate.or.kr/HESAS.


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