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Bioinformatics Advance Access published online on December 14, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti206
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Bioinformatics © Oxford University Press 2004; all rights reserved.
Received October 22, 2004
Revised December 2, 2004
Accepted December 2, 2004

Discovery note

The G5 domain: a potential N-acetylglucosamine recognition domain involved in biofilm formation

Alex Bateman 1, Matthew T. G. Holden 1, and Corin Yeats 1

1 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK


  Abstract

Summary: Biofilms are complex microbial communities found at surfaces that are often associated with extracellular polysaccharides. Biofilm formation is a complex process that is only recently being understood at the molecular level. We have identified a novel domain that we call the G5 domain (named after its conserved glycine residues) which is found in a variety of enzymes such as Streptococcal IgA peptidases and various glycosyl hydrolases in bacteria. The G5 domain is found in the Accumulation Associated Protein (AAP) that is an important component in biofilm formation in Staphylococcus aureus. A common feature of the proteins containing G5 domains is N-acetylglucosamine binding, and we attribute this function to the G5 domain.


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