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Bioinformatics Advance Access published online on December 10, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti209
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Bioinformatics © Oxford University Press 2004; all rights reserved.
Received September 17, 2004
Revised January 19, 2004
Accepted December 3, 2004

Applications note

In-silico fine-mapping: narrowing disease-associated loci by intergenomics

Pablo Serrano-Fernández 1, Saleh M. Ibrahim 1, Dirk Koczan 1, Uwe K. Zettl 2, and Steffen Möller 1

1 Institute of Immunology, University of Rostock, Schillingallee 70, D-18057 Rostock (Germany)
2 Institute of Neurology, University of Rostock, Schillingallee 70, D-18057 Rostock (Germany)


  Abstract

Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was created to identify intergenomic consensuses to fine map QTLs and SLs in silico and select particularly promising candidate genes for such traits. Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits.

Availability: http://qtl.pzr.uni-rostock.de/qtlmix.php.


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