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Bioinformatics Advance Access published online on December 14, 2004
Bioinformatics, doi:10.1093/bioinformatics/bti221
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Bioinformatics © Oxford University Press 2004; all rights reserved.
Received November 4, 2004
Revised November 28, 2004
Accepted December 12, 2004

Discovery note

The WHy domain mediates the response to desiccation in plants and bacteria

Francesca D. Ciccarelli 1* and Peer Bork 1

1 European Molecular Biology Laboratory, 69012 Heidelberg, Meyerhofstr. 1

* To whom correspondence should be addressed.
Francesca D. Ciccarelli, E-mail: francesca.ciccarelli{at}embl.de


  Abstract

Motivation: The Hypersensitive Response (HR) is a process activated by plants after microbial infection. Its main phenotypic effects are both a programmed death of the plant cells nearby the infection site and a reduction of the microbial proliferation. Although many resistance genes (R genes) associated to HR have been identified, very few is known about the molecular mechanisms activated after their expression.

Results: The analysis of the product of one of the R genes, the Hin1 protein, led to the identification of a novel domain, which we named WHy because it is detectable in proteins involved in water stress and hypersensitive response. The expression of this domain during both biotic infection and response to desiccation points to a molecular machinery common to these two stress conditions. Moreover, its presence in a restricted number of bacteria suggests a possible use for marking plant pathogenicity.

Supplementary Information: Supplementary data (Figure S1, Figure S2 and Table S1) and the alignment in clustal format are available at http://www.bork.embl.de/~ciccarel/WHy_add_data.html.


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