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Bioinformatics Advance Access published online on January 12, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti252
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Bioinformatics © Oxford University Press 2005; all rights reserved.
Received October 25, 2004
Revised December 22, 2004
Accepted December 23, 2004

Applications note

GOAnno: GO annotation based on multiple alignment

F. Chalmel 1*, A. Lardenois 1, J. D. Thompson 1, J. Muller 1, J.-A. Sahel 2, T. Léveillard 2, and O. Poch 1

1 Laboratoire de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, 67404 Illkirch cedex, France
2 Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, Inserm U592, Université Pierre et Marie Curie, 75571 Paris, France

* To whom correspondence should be addressed.
F. Chalmel, E-mail: chalmel{at}igbmc.u-strasbg.fr


  Abstract

Summary: GOAnno is a web tool that automatically annotates proteins according to the Gene Ontology (GO) using evolutionary information available in hierarchised multiple alignments. GO terms present in the aligned functional subfamily can be cross-validated and propagated to obtain highly reliable predicted GO annotation based on the GOAnno algorithm.

Availability: The web tool and a reduced version for local installation are freely available at: http://igbmc.u-strasbg.fr/GOAnno/GOAnno.html.

Supplementary information: The web site supplies a detailed explanation and illustration of the algorithm at: http://igbmc.u-strasbg.fr/GOAnno/GOAnnoHelp.html.


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