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Bioinformatics Advance Access published online on January 12, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti259
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Bioinformatics © Oxford University Press 2005; all rights reserved.
Received October 27, 2004
Revised December 27, 2004
Accepted December 30, 2004

Applications note

Selecton: a server for detecting evolutionary forces at a single amino-acid site

Adi Doron-Faigenboim 1, Adi Stern 1, Itay Mayrose 1, Eran Bacharach 1, and Tal Pupko 1*

1 Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel

* To whom correspondence should be addressed.
Tal Pupko, E-mail: talp{at}post.tau.ac.il


  Abstract

Summary: We present an algorithmic tool for the identification of biologically significant amino acids in proteins of known three dimensional structure. We estimate the degree of purifying selection and positive Darwinian selection at each site and project these estimates onto the molecular surface of the protein. Thus, patches of functional residues (undergoing either positive or purifying selection), which may be discontinuous in the linear sequence, are revealed. We test for the statistical significance of the site-specific scores in order to obtain reliable and valid estimates.

Availability: The Selecton web server is available at: http://selecton.bioinfo.tau.ac.il.

Supplementary information: More information is available at http://selecton.bioinfo.tau.ac.il/overview.html. A set of examples is available at http://selecton.bioinfo.tau.ac.il/gallery.html.


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