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Bioinformatics Advance Access published online on January 18, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti269
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Bioinformatics © Oxford University Press 2005; all rights reserved.
Received December 9, 2004
Revised January 7, 2005
Accepted January 8, 2005

Applications note

EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology

Pedro A. Reche 1*, Hong Zhang 2, John-Paul Glutting 2, and Ellis L. Reinherz 1

1 Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
2 Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA


  Abstract

Summary: EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently the database contains 4867 distinct peptide sequences from various sources, including 84 tumor associated antigens. The EPIMHC database is accessible through a web server that has been designed to facilitate research in computational vaccinology. Importantly, peptides resulting from a query can be selected to derive specific motif-matrices. Subsequently, these motif-matrices can be used in combination with a dynamic algorithm for predicting MHC-binding peptides from user-provided protein queries.

Availability: The EPIMHC database server is hosted by the Dana-Farber Cancer Institute at the site http://immunax.dfci.harvard.edu/bioinformatics/epimhc/.


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