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Bioinformatics Advance Access published online on January 28, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti293
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Bioinformatics © Oxford University Press 2005; all rights reserved.
Received November 5, 2004
Revised January 10, 2005
Accepted January 25, 2005

Applications note

TreeScan: a bioinformatic application to search for genotype/phenotype associations using haplotype trees

David Posada 1*, Taylor J. Maxwell 2, and Alan R. Templeton 2

1 Variagenics, Inc., 60 Hampshire Street, Cambridge, MA 02139
2 Department of Biology, Washington University, St. Louis, MO 63130-4899, USA

* To whom correspondence should be addressed.
David Posada, E-mail: dposada{at}uvigo.es


  Abstract

Summary: We present the software implementation of the tree scanning method to detect associations between genetic haplotypes and quantitative traits, utilizing the evolutionary history of the haplotypes, in samples of unrelated individuals.

Availability: The program is available for free under the GNU General Public License. A package including C source code, a Makefile, and Windows (DOS) and Macintosh binaries, can be downloaded from http://darwin.uvigo.es.


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