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Bioinformatics Advance Access published online on March 3, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti360
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received December 12, 2004
Revised February 15, 2005
Accepted February 25, 2005

Applications note

CoC: a database of universally conserved residues in protein folds

Jason E. Donald 1, Isaac A. Hubner 1, Veronica M. Rotemberg 1, Eugene I. Shakhnovich 1, and Leonid A. Mirny 2*

1 Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138
2 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16-343, Cambridge, MA 02139

* To whom correspondence should be addressed.
Leonid A. Mirny, E-mail: leonid{at}mit.edu


  Abstract

Summary: The Conservatism of Conservatism (CoC) database presents statistically analyzed information about the conservation of residue positions in folds across protein families.

Availability: On the web at http://kulibin.mit.edu/coc/.

Supplementary information: The website details the method and contains a FAQ and documentation.


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