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Bioinformatics Advance Access published online on April 6, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti412
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received January 2, 2005
Revised March 24, 2005
Accepted March 24, 2005

Applications note

ROBIN: a tool for genome rearrangement of block-interchanges

Chin Lung Lu 1*, Tsui Ching Wang 1, Ying Chih Lin 2, and Chuan Yi Tang 2

1 Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan, ROC
2 Department of Computer Science, National Tsing Hua University, Hsinchu 300, Taiwan, ROC

* To whom correspondence should be addressed.
Chin Lung Lu, E-mail: cllu{at}mail.nctu.edu.tw


  Abstract

Summary: ROBIN is a web server for analyzing genome rearrangement of block-interchanges between two chromosomal genomes. It takes two or more linear/circular chromosomes as its input, and computes the number of minimum block-interchange rearrangements between any two input chromosomes for transforming one chromosome into another and also determines an optimal scenario taking this number of rearrangements. The input can be either bacterial-size sequence data or landmark-order data. If the input is sequence data, ROBIN will automatically search for the identical landmarks that are the homologous/conserved regions shared by all the input sequences.

Availability: ROBIN is freely accessed at http://genome.life.nctu.edu.tw/ROBIN.


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[Abstract] [Full Text] [PDF]


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