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Bioinformatics Advance Access published online on April 26, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti453
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received January 31, 2005
Revised April 12, 2005
Accepted April 13, 2005

Applications note

Association mapping and fine mapping with TreeLD

Sebastian Zöllner 1*, Xiaoquan Wen 1, and Jonathan K. Pritchard 1

1 Department of Human Genetics, The University of Chicago, 920 E 58th St-CLSC 505, Chicago IL 60637, USA

* To whom correspondence should be addressed.
Sebastian Zöllner, E-mail: szoellne{at}genetics.bsd.uchicago.edu


  Abstract

Summary: The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled chromosomes at that position. TreeLD provides an easy-to-use interface and can be applied to case-control, TDT trio and quantitative trait data.

Availability: The program TreeLD is available on the Internet from http://pritch.bsd.uchicago.edu/software.html.


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