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Bioinformatics Advance Access published online on May 12, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti491
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received May 26, 2004
Revised April 12, 2005
Accepted May 6, 2005

Article

A criticality-based framework for task composition in multi-agent bioinformatics integration systems

Konstantinos A. Karasavvas 1*, Richard Baldock 2, and Albert Burger 3

1 School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK
2 Human Genetics Unit, Medical Research Council, Edinburgh, EH4 2XU, UK
3 School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK; Human Genetics Unit, Medical Research Council, Edinburgh, EH4 2XU, UK

* To whom correspondence should be addressed.
Konstantinos A. Karasavvas, E-mail: ceekk{at}macs.hw.ac.uk


  Abstract

Motivation: During task composition, such as can be found in distributed query processing, workflow systems and AI planning, decisions have to be made by the system and possibly by users with respect to how a given problem should be solved. Although there is often more than one correct way of solving a given problem, these multiple solutions do not necessarily lead to the same result. Some researchers are addressing this problem by providing data provenance information. Others use expert advice encoded in a supporting knowledge-base. In this paper we propose an approach that assesses the importance of such decisions with respect to the overall result. We present a way of measuring decision criticality and describe its potential use.

Results: A multi-agent bioinformatics integration system is used as the basis of a framework that faciliates such functionality. We propose an agent architecture and a concrete bioinformatics example (prototype) is used to show how certain decisions may not be critical in the context of more complex tasks.


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