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Bioinformatics Advance Access published online on June 14, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti541
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received March 24, 2005
Revised May 27, 2005
Accepted June 13, 2005

Applications note

IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

Zsuzsanna Dosztányi 1*, Veronika Csizmok 1, Peter Tompa 1, and István Simon 1

1 Institute of Enzymology, BRC, Hungarian Academy of Sciences, H-1518 Budapest, P.O.Box 7., Hungary

* To whom correspondence should be addressed.
Zsuzsanna Dosztányi, E-mail: zsuzsa{at}enzim.hu


  Abstract

Summary: Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-dimensional structure under native conditions. The IUPred server presents a novel algorithm for predicting such regions from amino acid sequences by estimating their total pairwise interresidue interaction energy, based on the assumption that IUP sequences do not fold due to their inability to form sufficient stabilizing interresidue interactions (Dosztányi, Z. et al. (2005) J. Mol. Biol. 347, 827-839). Optional to the prediction are built-in parameter sets optimized for predicting short or long disordered regions and structured domains.

Availability: The IUPred server is available for academic users at http://iupred.enzim.hu.


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