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Bioinformatics Advance Access published online on June 16, 2005

Bioinformatics, doi:10.1093/bioinformatics/bti548
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received February 8, 2005
Revised June 13, 2005
Accepted June 15, 2005

Applications note

MagicMatch - cross-referencing sequence identifiers across databases

Mike Smith 1, Victor Kunin 2, Leon Goldovsky 3, Anton J. Enright 4, and Christos A. Ouzounis 3*

1 Mullard Space Science Laboratory, Holmbury St. Mary, Dorking, Surrey RH5 6NT, UK
2 Microbial Ecology Program, DoE Joint Genome Institute, 2800 Mitchell Drive, Bldg 400-404, Walnut Creek, CA 94598, USA
3 Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
4 Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK

* To whom correspondence should be addressed.
Christos A. Ouzounis, E-mail: ouzounis{at}ebi.ac.uk


   Abstract

Motivation: At present, mapping of sequence identifiers across databases is a daunting, time-consuming and computationally expensive process, usually achieved by sequence similarity searches with strict threshold values.

Summary: We present a rapid and efficient method to map sequence identifiers across databases. The method uses the MD5 checksum algorithm for message integrity to generate sequence fingerprints and uses these fingerprints as hash strings to map sequences across databases. The program, called MagicMatch, is able to cross-link any of the major sequence databases within a few seconds on a modest desktop computer.

Availability: MagicMatch is available at the following URL: http://cgg.ebi.ac.uk/services/magicmatch/, including an interactive service for major databases and binary downloads for widely used platforms.


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