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Bioinformatics Advance Access published online on June 30, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti563
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received May 9, 2005
Revised June 24, 2005
Accepted June 27, 2005

Applications note

TICO: a tool for improving predictions of prokaryotic translation initiation sites

M. Tech 1*, N. Pfeifer 1, B. Morgenstern 1, and P. Meinicke 1

1 Abteilung Bioinformatik, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Goldschmidtstr. 1, 37077 Göttingen, Germany

* To whom correspondence should be addressed.
M. Tech, E-mail: maike{at}gobics.de


  Abstract

Summary: We provide the tool "TICO" (Translation Initiation site COrrection) for improving the results of conventional gene finders for prokaryotic genomes with regard to exact localization of the translation initiation site. At the current state TICO provides an interface for direct post processing of the predictions obtained from the widely used program GLIMMER. Our program is based on a clustering algorithm for completely unsupervised scoring of potential TIS locations.

Availability: Our tool can be freely accessed through a web interface at http://tico.gobics.de/.


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